On top of that, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant forced overexpression of Ex4a(+)WT1 isoform. These success indicated that endogenous Ex4a(+)WT1 experienced a physiological function to promote apoptosis.DiscussionThe WT1 gene provides 4 big isoforms by substitute splicing of exon five (17AA) and exon 9 (KTS). All 4 important isoforms are o