HT-1080 cells have been transfected with Ex4a(+)WT1 isoform or Mock, and analyzed for apoptosis and mitochondrial damages (Fig 6A). Ex4a(+)WT1 isoform appreciably induced apoptosis and mitochondrial membrane prospective (MMP) reduction in HT-1080 cells. Subsequent, the job in the endogenous Ex4a(+)WT1 isoform in apoptosis was examined. K562 cells were being treated with Doxorubicin (Dox) and apopt