(LSD1) to repress HIV-1 transcription and viral expression in a synergistic manner (128). The recruitment of LSD1 at the HIV-1 proximal promoter has been associated with both H3K4me3 and H3K9me3 epigenetic marks, which is linked to the recruitment of hSet1 and WDR5, two members of the hCOMPASS complex, on the HIV-1 promoter (128). Recruitment of CTIP2 on the p21 promoter also induces a heterochrom