The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory area but lacked the zinc finger DNA-binding domain, and so the truncated Ex4a(+)WT1 isoform retained the opportunity to communicate with the transcriptional co-activators but missing a chance to bind to promoter of downstream targets. Earlier scientific studies have shown which the N-terminal domainPLOS